If the first translation of a text on smallpox vaccination in Japan was finished in 1820, how did it take another 29 years for the first mass vaccination campaigns to begin? The answers involve everything from a German doctor accused of being a spy to networks of physicians trying to navigate obscure bureaucracy. And they might remind you more of the last few years than you’d think.
The elimination of smallpox is probably one of the greatest medical accomplishments in human history. The vaccine that made it possible, however, was invented during a time of isolation for Japan. So how did the vaccine make it to Japanese shores, and what does that story tell us about public health, the sharing of information, and the nature of society in late feudal Japan?
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